ABSTRACT
Una córnea transparente es esencial para una excelente visión; es por eso que es avascular. Pero existen condiciones que favorecen la invasión de neovasos al tejido corneal, como infecciones, inflamación, hipoxia, trauma, entre otras, que reducen la calidad visual y en algunos casos llegan hasta la pérdida de esta. La neovascularización corneal representa un problema importante de salud pública a nivel mundial. Se realizó una búsqueda automatizada con el objetivo de encontrar información actualizada sobre el tratamiento de la neovascularización corneal, para lo cual se utilizó la plataforma infomed. La información se resumió en el documento final. Sobre el tema, existe un progreso notable en el entendimiento de la patogénesis, el mejoramiento y la seguridad de los nuevos tratamientos. Los corticoesteroides y los agentes anti-VEGF (factor de crecimiento endotelial vascular) continúan siendo los medicamentos de primera línea, usados principalmente para evitar la formación de los nuevos vasos, no así para vasos maduros, donde la mejor opción son los procedimientos quirúrgicos o combinados. Se necesitan más estudios experimentales, y los ya existentes deben ser utilizados en ensayos clínicos para investigar sobre la dosis segura y los efectos secundarios, y así encontrar terapias radicales, más eficaces, que le den a los pacientes con neovascularización corneal la esperanza de una mejor calidad visual(AU)
A clear cornea is essential for excellent vision; that is why it is avascular. But there are conditions that favor the invasion of neovessels into the corneal tissue, such as infections, inflammation, hypoxia, trauma, among others, which reduce visual quality and in some cases even lose it. Corneal neovascularization represents a major public health problem worldwide. An automated search was carried out in order to find updated information on the treatment of corneal neovascularization, for which the infomed platform was used. The information was summarized in the final document. On the subject, there is notable progress in understanding the pathogenesis, improvement and safety of new treatments. Corticosteroids and anti-VEGF (vascular endothelial growth factor) agents continue to be the first-line drugs, used mainly to prevent the formation of new vessels, not for mature vessels, where the best option is surgical or combined procedures. More experimental studies are needed; and the existing ones should be used in clinical trials to investigate the safe dose and side effects, and thus find radical and more effective therapies that give patients with corneal neovascularization the hope of better visual quality(AU)
Subject(s)
Humans , Surgical Procedures, Operative/methods , Corneal Neovascularization/drug therapy , Adrenal Cortex Hormones/therapeutic use , Vascular Endothelial Growth Factor A/therapeutic use , Review Literature as TopicABSTRACT
In this report, we report the case of a 7-year-old boy with corneal neovascularization due to exposure keratopathy following cerebellar astrocytoma surgery. Corneal surface healing was achieved with topical treatment and therapeutic contact lens, after which topical steroid was administered for stromal haze and corneal neovascularization. After 2 months of steroid therapy failed, corneal neovascularization responded well to topical aflibercept administration, showing complete regression.
ABSTRACT
As far as we can ascertain in the literature, this is the first time cryogenic procedure has been applied to the difficult problem of obliterating or artificially regressing corneal blood vesselsUtilizing-50 degree celsius we froze a series of 25 cases of vascularized corneas and have carefully and systematically observed clinically the obliteration and complete regression of the blood vessels by the aid of biomicroscope, operating microscope and with the help of intravenous flourescein. Diagrams of the individual vessels were recorded and photographs of various stages of regression were takenHistopathological examinations of the frozen corneal tissues were made. Photomicrographs of the sections showed the death, disintegration, disapperance of the endotholial cells of the blood vesel with extravasation, some inflammatory reaction and complete disappearance of the vessels. The changes in the non-vascular, cellular and non-cellular structures have been shown. Several cases of frozen vascularized cornea have been subjected to keratoplasty after 4 to 5 months with more favorable results than if the corneal freezing had not been done. (Summary)